論文 - 詳細
| RRC ID | 66866 |
|---|---|
| 著者 | Ishida-Ishihara S, Akiyama M, Furusawa K, Naguro I, Ryuno H, Sushida T, Ishihara S, Haga H. |
| タイトル | Osmotic gradients induce stable dome morphogenesis on extracellular matrix. |
| ジャーナル | J Cell Sci |
| Abstract |
One of the fundamental processes in morphogenesis is dome formation, but many of the mechanisms involved are unexplored. Previous in vitro studies showed that an osmotic gradient is the driving factor of dome formation. However, these investigations were performed without extracellular matrix (ECM), which provides structural support to morphogenesis. With the use of ECM, we observed that basal hypertonic stress induced stable domes in vitro that have not been seen in previous studies. These domes developed as a result of ECM swelling via aquaporin water transport activity. Based on computer simulation, uneven swelling, with a positive feedback between cell stretching and enhanced water transport, was a cause of dome formation. These results indicate that osmotic gradients induce dome morphogenesis via both enhanced water transport activity and subsequent ECM swelling. |
| 巻・号 | 133(14) |
| 公開日 | 2020-7-27 |
| DOI | 10.1242/jcs.243865 |
| PII | jcs.243865 |
| PMID | 32576662 |
| MeSH | Computer Simulation Extracellular Matrix* Morphogenesis Osmosis Osmotic Pressure |
| IF | 4.573 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MDCK(RCB0995) |