論文 - 詳細
| RRC ID | 66879 |
|---|---|
| 著者 | Sasaki H, Kubohara Y, Ishigaki H, Takahashi K, Eguchi H, Sugawara A, Oshima Y, Kikuchi H. |
| タイトル | Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds. |
| ジャーナル | Molecules |
| Abstract |
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry. |
| 巻・号 | 25(12) |
| 公開日 | 2020-6-23 |
| DOI | 10.3390/molecules25122895 |
| PII | molecules25122895 |
| PMID | 32585998 |
| PMC | PMC7356884 |
| MeSH | Animals Anti-Bacterial Agents / pharmacology Antineoplastic Agents / pharmacology Biosynthetic Pathways / drug effects Dictyostelium / chemistry* Dictyostelium / metabolism Escherichia coli / drug effects HeLa Cells Humans Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Mice Microbial Sensitivity Tests Osteogenesis / drug effects RAW 264.7 Cells Staphylococcus aureus / drug effects Terpenes / chemistry Terpenes / isolation & purification* Terpenes / pharmacology |
| IF | 3.267 |
| リソース情報 | |
| 細胞性粘菌 | S00218(Dm7) |