論文 - 詳細
| RRC ID | 67084 |
|---|---|
| 著者 | Momose I, Onodera T, Doi H, Adachi H, Iijima M, Yamazaki Y, Sawa R, Kubota Y, Igarashi M, Kawada M. |
| タイトル | Leucinostatin Y: A Peptaibiotic Produced by the Entomoparasitic Fungus Purpureocillium lilacinum 40-H-28. |
| ジャーナル | J Nat Prod |
| Abstract |
Leucinostatin Y, a new peptaibiotic, was isolated from the culture broth of the entomoparasitic fungus Purpureocillium lilacinum 40-H-28. The planar structure was elucidated by detailed analysis of its NMR and MS/MS data. The absolute configurations of the amino acids were partially determined by an advanced Marfey's method. The biological activities of leucinostatin Y were assessed using human pancreatic cancer cells, revealing the importance of the C-terminus of leucinostatins for preferential cytotoxicity to cancer cells under glucose-deprived conditions and inhibition of mitochondrial function. |
| 巻・号 | 82(5) |
| ページ | 1120-1127 |
| 公開日 | 2019-5-24 |
| DOI | 10.1021/acs.jnatprod.8b00839 |
| PMID | 31017786 |
| MeSH | Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology Cell Line, Tumor Humans Magnetic Resonance Spectroscopy Paecilomyces / chemistry* Pancreatic Neoplasms / drug therapy Pancreatic Neoplasms / pathology Peptaibols / chemistry Peptaibols / isolation & purification* Peptaibols / pharmacology |
| IF | 3.782 |
| リソース情報 | |
| ヒト・動物細胞 | PK-8(RCB2700) |