Reference - Detail
| RRC ID | 67107 |
|---|---|
| Author | Nakamura S, Chen G, Nakashima S, Matsuda H, Pei Y, Yoshikawa M. |
| Title | Brazilian natural medicines. IV. New noroleanane-type triterpene and ecdysterone-type sterol glycosides and melanogenesis inhibitors from the roots of Pfaffia glomerata. |
| Journal | Chem Pharm Bull (Tokyo) |
| Abstract |
The ethyl acetate and 1-butanol soluble fractions of the roots of Pfaffia glomerata were found to show inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. From the ethyl acetate and 1-butanol soluble fractions, we isolated a new noroleanane-type triterpene, pfaffianol A, its glycosides, pfaffiaglycosides A and B, and ecdysterone-type sterol glycosides, pfaffiaglycosides C, D, and E, together with eight known constituents. The structures of new constituents were determined on the basis of physicochemical and chemical evidence. Among them, pfaffianol A (IC(50)=44 microM) and pfaffoside C (IC(50)=92 microM) substantially inhibited melanogenesis without cytotoxic effects. The inhibitory effects were stronger than that of reference compound, arbutin (IC(50)=174 microM). |
| Volume | 58(5) |
| Pages | 690-5 |
| Published | 2010-5-1 |
| DOI | 10.1248/cpb.58.690 |
| PII | JST.JSTAGE/cpb/58.690 |
| PMID | 20460798 |
| MeSH | Amaranthaceae / chemistry* Animals Antineoplastic Agents* / chemistry Antineoplastic Agents* / pharmacology Brazil Cell Line, Tumor Cell Survival / drug effects Drug Screening Assays, Antitumor Ecdysterone / chemistry* Ecdysterone / pharmacology Glycosides / chemistry* Glycosides / pharmacology Magnetic Resonance Spectroscopy Melanoma, Experimental* Mice Oleanolic Acid / chemistry* Oleanolic Acid / pharmacology Plant Extracts / chemistry Plant Roots / chemistry* Sterols / chemistry Sterols / pharmacology |
| IF | 1.416 |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) |