論文 - 詳細
| RRC ID | 67111 |
|---|---|
| 著者 | Cheng CC, Tsutsui K, Taguchi T, Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H. |
| タイトル | Hair follicle epidermal stem cells define a niche for tactile sensation. |
| ジャーナル | Elife |
| Abstract |
The heterogeneity and compartmentalization of stem cells is a common principle in many epithelia, and is known to function in epithelial maintenance, but its other physiological roles remain elusive. Here we show transcriptional and anatomical contributions of compartmentalized epidermal stem cells in tactile sensory unit formation in the mouse hair follicle. Epidermal stem cells in the follicle upper-bulge, where mechanosensory lanceolate complexes innervate, express a unique set of extracellular matrix (ECM) and neurogenesis-related genes. These epidermal stem cells deposit an ECM protein called EGFL6 into the collar matrix, a novel ECM that tightly ensheathes lanceolate complexes. EGFL6 is required for the proper patterning, touch responses, and αv integrin-enrichment of lanceolate complexes. By maintaining a quiescent original epidermal stem cell niche, the old bulge, epidermal stem cells provide anatomically stable follicle-lanceolate complex interfaces, irrespective of the stage of follicle regeneration cycle. Thus, compartmentalized epidermal stem cells provide a niche linking the hair follicle and the nervous system throughout the hair cycle. |
| 巻・号 | 7 |
| 公開日 | 2018-10-25 |
| DOI | 10.7554/eLife.38883 |
| PII | 38883 |
| PMID | 30355452 |
| PMC | PMC6226291 |
| MeSH | Animals Axons / metabolism Calcium-Binding Proteins Cell Adhesion Cell Adhesion Molecules Epidermal Cells / cytology* Epidermal Cells / metabolism Epidermal Cells / ultrastructure Extracellular Matrix / metabolism Extracellular Matrix Proteins / metabolism Gene Expression Regulation Glycoproteins / metabolism Hair Follicle / cytology* Hair Follicle / innervation Integrin alphaV / metabolism Mice, Knockout Neoplasm Proteins / metabolism Neurons / cytology Peptides / metabolism Schwann Cells / metabolism Stem Cell Niche* Stem Cells / cytology* Stem Cells / metabolism Stem Cells / ultrastructure Touch / physiology* |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293(RCB1637) |