論文 - 詳細
| RRC ID | 67214 |
|---|---|
| 著者 | Phan CS, Matsuda K, Balloo N, Fujita K, Wakimoto T, Okino T. |
| タイトル | Argicyclamides A-C Unveil Enzymatic Basis for Guanidine Bis-prenylation. |
| ジャーナル | J Am Chem Soc |
| Abstract |
Guanidine prenylation is an outstanding modification in alkaloid and peptide biosynthesis, but its enzymatic basis has remained elusive. We report the isolation of argicyclamides, a new class of cyanobactins with unique mono- and bis-prenylations on guanidine moieties, from Microcystis aeruginosa NIES-88. The genetic basis of argicyclamide biosynthesis was established by the heterologous expression and in vitro characterization of biosynthetic enzymes including AgcF, a new guanidine prenyltransferase. This study provides important insight into the biosynthesis of prenylated guanidines and offers a new toolkit for peptide modification. |
| 巻・号 | 143(27) |
| ページ | 10083-10087 |
| 公開日 | 2021-7-14 |
| DOI | 10.1021/jacs.1c05732 |
| PMID | 34181406 |
| MeSH | Guanidine / chemistry* Guanidine / metabolism* Microcystis / metabolism* Molecular Structure Peptides, Cyclic / chemistry* Peptides, Cyclic / metabolism* Prenylation |
| IF | 14.612 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 藻類 | NIES-88 |