RRC ID 67252
Author Nakashima S, Oda Y, Nakamura S, Liu J, Onishi K, Kawabata M, Miki H, Himuro Y, Yoshikawa M, Matsuda H.
Title Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna).
Journal Bioorg Med Chem Lett
Abstract The methanolic extract of Lawsonia inermis L. (henna) showed significant inhibitory activity toward melanogenesis in B16 melanoma 4A5 cells. Among the constituents isolated from the methanolic extract, luteolin, quercetin, and (±)-eriodictyol showed stronger inhibitory activity than the reference compound, arbutin. Several structure-activity relationships of the flavonoids were suggested, and OGlc
Volume 25(13)
Pages 2702-6
Published 2015-7-1
DOI 10.1016/j.bmcl.2015.04.052
PII S0960-894X(15)00384-4
PMID 25987378
MeSH Animals Antifibrinolytic Agents / chemistry Antifibrinolytic Agents / isolation & purification Antifibrinolytic Agents / pharmacology Cell Line, Tumor Cell Proliferation / drug effects Flavonoids / chemistry* Flavonoids / isolation & purification Flavonoids / pharmacology* Flowers / chemistry Humans Intramolecular Oxidoreductases / antagonists & inhibitors Intramolecular Oxidoreductases / genetics Lawsonia Plant / chemistry* Melanins / biosynthesis* Melanoma, Experimental / drug therapy* Melanoma, Experimental / genetics Melanoma, Experimental / metabolism* Mice Monophenol Monooxygenase / antagonists & inhibitors Monophenol Monooxygenase / genetics Oxidoreductases / antagonists & inhibitors Oxidoreductases / genetics Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology Plants, Medicinal / chemistry RNA, Messenger / genetics RNA, Messenger / metabolism RNA, Neoplasm / genetics RNA, Neoplasm / metabolism Structure-Activity Relationship
IF 2.572
Resource
Human and Animal Cells B16 melanoma 4A5(RCB0557)