論文 - 詳細
| RRC ID | 67295 |
|---|---|
| 著者 | Okamoto S, Iwasaki A, Ohno O, Suenaga K. |
| タイトル | Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes. |
| ジャーナル | J Nat Prod |
| Abstract |
Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC50 values of 8.1 and 9.0 μM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved. |
| 巻・号 | 78(11) |
| ページ | 2719-25 |
| 公開日 | 2015-11-25 |
| DOI | 10.1021/acs.jnatprod.5b00662 |
| PMID | 26539973 |
| MeSH | Cyanobacteria / chemistry* Depsipeptides / chemistry Drug Screening Assays, Antitumor HL-60 Cells HeLa Cells Humans Lipopeptides / chemical synthesis* Lipopeptides / chemistry Lipopeptides / isolation & purification* Marine Biology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Peptides, Cyclic / chemistry |
| IF | 3.782 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa HL60 |