| RRC ID |
67352
|
| Author |
Tsurushima H, Liu SQ, Tuboi K, Matsumura A, Yoshii Y, Nose T, Saijo K, Ohno T.
|
| Title |
Reduction of end-stage malignant glioma by injection with autologous cytotoxic T lymphocytes.
|
| Journal |
Jpn J Cancer Res
|
| Abstract |
Autologous cytotoxic T lymphocytes (CTL) against primary-cultured malignant gliomas were generated from peripheral blood mononuclear cells in vitro in 4 patients. Activities of the CTL were highly specific to the corresponding autologous glioma and were inhibited, in one patient, with antibodies against CD3, CD8 and MHC-class I molecules. When the CTL were injected 3 times into the primary-tumor-resected cavity via an Ommaya tube, reduction of the recurrent tumors with magnetic resonance imaging (MRI)-measured volumes exceeding 45 cm3 was observed in 3 patients. In a patient with glioblastoma multiforme (GBM), the tumor volume (estimated, 130 cm3) was rapidly reduced to 1/3, although re-recurrence of the tumor followed 40 days later. A slight but distinct rapid reduction of the tumor volume was observed in another GBM patient and in an anaplastic astrocytoma patient; essentially no change was observed in a further GBM patient. These results suggest that adoptive immunotherapy with autologous CTL will be clinically effective against end-stage malignant gliomas.
|
| Volume |
90(5)
|
| Pages |
536-45
|
| Published |
1999-5-1
|
| DOI |
10.1111/j.1349-7006.1999.tb00781.x
|
| PII |
S091050509980115X
|
| PMID |
10391094
|
| PMC |
PMC5926095
|
| MeSH |
Adult
Antigens, CD / blood
Antigens, Surface / blood
Disease Progression
Female
Glioblastoma / pathology
Glioblastoma / therapy*
Humans
Immunophenotyping
Immunotherapy, Adoptive*
Magnetic Resonance Imaging
Male
Middle Aged
T-Lymphocytes, Cytotoxic / transplantation*
Transplantation, Autologous
|
| Resource |
| Human and Animal Cells |
TUHR3TKB(RCB1187)
TUHR4TKB(RCB1198)
OS-RC-2(RCB0735) |
