| RRC ID |
67381
|
| 著者 |
Wilhelmus MM, Boelens WC, Kox M, Maat-Schieman ML, Veerhuis R, de Waal RM, Verbeek MM.
|
| タイトル |
Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion.
|
| ジャーナル |
Neurobiol Aging
|
| Abstract |
In hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), severe cerebral amyloid angiopathy (CAA) is associated with an inflammatory reaction. Small heat shock proteins (sHsps) are molecular chaperones and association of HspB8 with CAA in HCHWA-D has been observed. The aims of this study were to investigate (1) if other sHsps are associated with the pathological lesions in HCHWA-D brains, (2) if the amyloid-beta protein (A beta) increases production of sHsps in cultured cerebral cells and (3) if sHsps are involved in the cerebral inflammatory processes in both Alzheimer's disease (AD) and HCHWA-D. We conclude that Hsp20, HspB8 and HspB2 are present in CAA in HCHWA-D, and that A beta did not affect cellular sHsps expression in cultured human brain pericytes and astrocytes. In addition, we demonstrated that Hsp20, HspB2 and HspB8 induced interleukin-6 production in cultured pericytes and astrocytes, which could be antagonized by dexamethasone, whereas other sHsps and A beta were inactive, suggesting that sHsps may be among the key mediators of the local inflammatory response associated with HCHWA-D and AD lesions.
|
| 巻・号 |
30(2)
|
| ページ |
229-40
|
| 公開日 |
2009-2-1
|
| DOI |
10.1016/j.neurobiolaging.2007.06.001
|
| PII |
S0197-4580(07)00242-4
|
| PMID |
17629591
|
| MeSH |
Cerebral Amyloid Angiopathy, Familial / metabolism*
Female
Frontal Lobe / metabolism*
Heat-Shock Proteins / metabolism*
Humans
Interleukin-6 / metabolism*
Male
Middle Aged
|
| IF |
4.347
|
| リソース情報 |
| ヒト・動物細胞 |
anti-αB-crystallin(RCB1304) |
