Reference - Detail
| RRC ID | 67395 |
|---|---|
| Author | Oshima T, Takahashi K, Inada A, Yamasaki M, Yamasaki Y, Eto N. |
| Title | Enhanced water dispersibility and permeability through a Caco-2 cell monolayer of β-cryptoxanthin extracted from kumquats by complexation with casein. |
| Journal | Food Chem |
| Abstract |
β-Cryptoxanthin (BCX) possesses potential therapeutic and health benefits. However, BCX absorption is low because of its poor aqueous solubility. In this study, a complex between BCX and casein (Cas) was prepared to improve the water dispersibility and bioavailability of BCX. BCX was recovered quantitatively from freeze-dried kumquat powder through solid-liquid extraction and saponification. The complexation significantly improved the apparent solubility of BCX under acidic and neutral conditions. A cell membrane permeation test using a Caco-2 cell monolayer was performed to evaluate the bioavailability of the BCX-Cas complex. This complex and a blank sample were digested in vitro and added to the apical side of the Caco-2 cell membrane. The quantity of BCX that permeated using the BCX-Cas complex after 24 h was 22.7 times greater than that of the blank. Thus, complexation of BCX with Cas improved dramatically the bioavailability of BCX from a kumquat extract. |
| Volume | 360 |
| Pages | 129822 |
| Published | 2021-10-30 |
| DOI | 10.1016/j.foodchem.2021.129822 |
| PII | S0308-8146(21)00828-1 |
| PMID | 33984564 |
| MeSH | Beta-Cryptoxanthin / chemistry* Caco-2 Cells Caseins / chemistry* Humans Permeability Plant Extracts / chemistry Rutaceae / chemistry* Solubility Water / chemistry |
| IF | 6.306 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | CACO-2(RCB0988) |