RRC ID 67421
Author Iwamoto Y, Kodera M, Hitomi Y.
Title Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}(6) complex.
Journal Chem Commun (Camb)
Abstract The photo-initiated cytotoxicity of a newly developed manganese nitrosyl {MnNO}(6) complex (UG1NO) to HeLa cells is described. The complex was found to be strongly cytotoxic after being exposed to light with a wavelength of 650 nm. Cell death was caused by a manganese(II) complex, UG1, generated from UG1NO through the photo-dissociation of NO, rather than by NO directly. Mechanistic studies revealed that UG1 consumes O2 only in the presence of a reducing agent to catalytically produce H2O2.
Volume 51(46)
Pages 9539-42
Published 2015-6-11
DOI 10.1039/c5cc02566d
PMID 25967395
IF 6.164
Resource
Human and Animal Cells HeLa(RCB0007)