Reference - Detail
| RRC ID | 67421 |
|---|---|
| Author | Iwamoto Y, Kodera M, Hitomi Y. |
| Title | Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}(6) complex. |
| Journal | Chem Commun (Camb) |
| Abstract |
The photo-initiated cytotoxicity of a newly developed manganese nitrosyl {MnNO}(6) complex (UG1NO) to HeLa cells is described. The complex was found to be strongly cytotoxic after being exposed to light with a wavelength of 650 nm. Cell death was caused by a manganese(II) complex, UG1, generated from UG1NO through the photo-dissociation of NO, rather than by NO directly. Mechanistic studies revealed that UG1 consumes O2 only in the presence of a reducing agent to catalytically produce H2O2. |
| Volume | 51(46) |
| Pages | 9539-42 |
| Published | 2015-6-11 |
| DOI | 10.1039/c5cc02566d |
| PMID | 25967395 |
| MeSH | Antineoplastic Agents* / chemistry Antineoplastic Agents* / pharmacology Antineoplastic Agents* / radiation effects Catalysis Cell Survival / drug effects Coordination Complexes* / chemistry Coordination Complexes* / pharmacology Coordination Complexes* / radiation effects Glutathione / metabolism HeLa Cells Humans Hydrogen Peroxide / chemistry* Light Manganese* / chemistry Manganese* / pharmacology Manganese* / radiation effects Nitric Oxide / chemistry* |
| IF | 5.996 |
| Resource | |
| Human and Animal Cells | HeLa(RCB0007) |