RRC ID 67424
著者 Nagasaka R, Ishikawa Y, Inada T, Ohshima T.
タイトル Depigmenting Effect of Winter Medicinal Mushroom Flammulna velutipes (Higher Basidiomycetes) on Melanoma Cells.
ジャーナル Int J Med Mushrooms
Abstract In humans, skin pigmentation results from the biochemichal synthesis and accumulation of melanin. We previously revealed that edible winter mushroom Flammulina velutipes extract inhibited melanosis in commercially available edible crustacea. Therefore, the current study was conducted to find if edible mushrooms extracts are useful for the skin whitening and the underlying mechanisms in melanin biosynthesis. Tyrosinase is one of the key enzymes for melanin biosynthesis. This study demonstrated that melanin synthesis and tyrosinase activity were suppressed by the F. velutipes extracts in B16 murine melanoma cells through the slow expression of microphthalmia-associated transcription factor. These results suggested that the F. velutipes extract could contain an effective component in whitening cosmetics and an alternative therapeutic agent for treating hyperpigmentation.
巻・号 17(6)
ページ 511-20
公開日 2015-1-1
DOI 10.1615/intjmedmushrooms.v17.i6.20
PII 52f67ca6221cc3fa,54f0b743251c75b9
PMID 26349509
MeSH Animals Cell Line, Tumor Enzyme Inhibitors / isolation & purification* Enzyme Inhibitors / metabolism* Flammulina / chemistry* Humans Melanins / antagonists & inhibitors* Melanins / biosynthesis* Mice Monophenol Monooxygenase / antagonists & inhibitors* Transcription Factors / antagonists & inhibitors*
リソース情報
ヒト・動物細胞 B16 melanoma