| RRC ID |
67450
|
| 著者 |
Morinaga M, Sako N, Isobe M, Lee-Hotta S, Sugiura H, Kametaka S.
|
| タイトル |
Aerobic Exercise Ameliorates Cancer Cachexia-Induced Muscle Wasting through Adiponectin Signaling.
|
| ジャーナル |
Int J Mol Sci
|
| Abstract |
Cachexia is a multifactorial syndrome characterized by muscle loss that cannot be reversed by conventional nutritional support. To uncover the molecular basis underlying the onset of cancer cachectic muscle wasting and establish an effective intervention against muscle loss, we used a cancer cachectic mouse model and examined the effects of aerobic exercise. Aerobic exercise successfully suppressed muscle atrophy and activated adiponectin signaling. Next, a cellular model for cancer cachectic muscle atrophy using C2C12 myotubes was prepared by treating myotubes with a conditioned medium from a culture of colon-26 cancer cells. Treatment of the atrophic myotubes with recombinant adiponectin was protective against the thinning of cells through the increased production of p-mTOR and suppression of LC3-II. Altogether, these findings suggest that the activation of adiponectin signaling could be part of the molecular mechanisms by which aerobic exercise ameliorates cancer cachexia-induced muscle wasting.
|
| 巻・号 |
22(6)
|
| 公開日 |
2021-3-18
|
| DOI |
10.3390/ijms22063110
|
| PII |
ijms22063110
|
| PMID |
33803685
|
| PMC |
PMC8002946
|
| MeSH |
Adiponectin / genetics
Adiponectin / metabolism*
Animals
Cachexia / complications*
Cachexia / metabolism*
Cell Line, Tumor
Culture Media, Conditioned / pharmacology
Disease Models, Animal
Female
Mice
Mice, Inbred BALB C
Microtubule-Associated Proteins / metabolism
Muscle Fibers, Skeletal / drug effects
Muscle Fibers, Skeletal / metabolism
Muscle, Skeletal / drug effects
Muscle, Skeletal / pathology
Muscular Atrophy / complications*
Muscular Atrophy / metabolism*
Muscular Atrophy / pathology
Phosphorylation / drug effects
Physical Conditioning, Animal*
Protein Biosynthesis / drug effects
Proto-Oncogene Proteins c-akt / metabolism
RNA, Messenger / genetics
RNA, Messenger / metabolism
Recombinant Proteins / pharmacology
Signal Transduction*
|
| IF |
4.556
|
| リソース情報 |
| ヒト・動物細胞 |
Colon-26(RCB2657) |
