論文 - 詳細
| RRC ID | 67567 |
|---|---|
| 著者 | Ding G, Xiang X, Hu Y, Xiao G, Chen Y, Binari R, Comjean A, Li J, Rushworth E, Fu Z, Mohr SE, Perrimon N, Song W. |
| タイトル | Coordination of tumor growth and host wasting by tumor-derived Upd3. |
| ジャーナル | Cell Rep |
| Abstract |
yki-induced gut tumors in Drosophila are associated with host wasting, including muscle dysfunction, lipid loss, and hyperglycemia, a condition reminiscent of human cancer cachexia. We previously used this model to identify tumor-derived ligands that contribute to host wasting. To identify additional molecular networks involved in host-tumor interactions, we develop PathON, a web-based tool analyzing the major signaling pathways in Drosophila, and uncover the Upd3/Jak/Stat axis as an important modulator. We find that yki-gut tumors secrete Upd3 to promote self-overproliferation and enhance Jak/Stat signaling in host organs to cause wasting, including muscle dysfunction, lipid loss, and hyperglycemia. We further reveal that Upd3/Jak/Stat signaling in the host organs directly triggers the expression of ImpL2, an antagonistic binding protein for insulin-like peptides, to impair insulin signaling and energy balance. Altogether, our results demonstrate that yki-gut tumors produce a Jak/Stat pathway ligand, Upd3, that regulates both self-growth and host wasting. |
| 巻・号 | 36(7) |
| ページ | 109553 |
| 公開日 | 2021-8-17 |
| DOI | 10.1016/j.celrep.2021.109553 |
| PII | S2211-1247(21)00987-6 |
| PMID | 34407411 |
| PMC | PMC8410949 |
| MeSH | Animals Cell Proliferation Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism* Fat Body / metabolism Homeostasis Insulin / metabolism Intestines / cytology Janus Kinases / metabolism Lipid Metabolism Mitochondria / metabolism Mitochondria / ultrastructure Muscles / physiopathology Neoplasms / metabolism* Neoplasms / pathology* STAT Transcription Factors / metabolism Signal Transduction Stem Cells / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 4.0 |
| リソース情報 | |
| ショウジョウバエ | 15009R-3 |