論文 - 詳細
| RRC ID | 67685 |
|---|---|
| 著者 | Takahashi A, Nagayasu K, Nishitani N, Kaneko S, Koide T. |
| タイトル | Control of intermale aggression by medial prefrontal cortex activation in the mouse. |
| ジャーナル | PLoS One |
| Abstract |
Aggressive behavior is widely observed throughout the animal kingdom because of its adaptiveness for social animals. However, when aggressive behavior exceeds the species-typical level, it is no longer adaptive, so there should be a mechanism to control excessive aggression to keep it within the adaptive range. Using optogenetics, we demonstrate that activation of excitatory neurons in the medial prefrontal cortex (mPFC), but not the orbitofrontal cortex (OFC), inhibits inter-male aggression in mice. At the same time, optogenetic silencing of mPFC neurons causes an escalation of aggressive behavior both quantitatively and qualitatively. Activation of the mPFC suppresses aggressive bursts and reduces the intensity of aggressive behavior, but does not change the duration of the aggressive bursts. Our findings suggest that mPFC activity has an inhibitory role in the initiation and execution, but not the termination, of aggressive behavior, and maintains such behavior within the adaptive range. |
| 巻・号 | 9(4) |
| ページ | e94657 |
| 公開日 | 2014-1-1 |
| DOI | 10.1371/journal.pone.0094657 |
| PII | PONE-D-14-02867 |
| PMID | 24740241 |
| PMC | PMC3989250 |
| MeSH | Aggression / physiology* Animals Female Light Luminescent Proteins / genetics Luminescent Proteins / metabolism Male Mice, Inbred C57BL Mice, Inbred ICR Microscopy, Fluorescence Motor Activity / physiology* Neurons / physiology* Neurons / virology Optogenetics / methods Prefrontal Cortex / cytology Prefrontal Cortex / physiology* Prefrontal Cortex / virology |
| IF | 2.74 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | CSII-EF-Venus (RDB05552) |