RRC ID 67722
著者 Krishnan V, Kasuya Y, Ji Q, Sathish M, Shrestha LK, Ishihara S, Minami K, Morita H, Yamazaki T, Hanagata N, Miyazawa K, Acharya S, Nakanishi W, Hill JP, Ariga K.
タイトル Vortex-aligned fullerene nanowhiskers as a scaffold for orienting cell growth.
ジャーナル ACS Appl Mater Interfaces
Abstract A versatile method for the rapid fabrication of aligned fullerene C60 nanowhiskers (C60NWs) at the air-water interface is presented. This method is based on the vortex motion of a subphase (water), which directs floating C60NWs to align on the water surface according to the direction of rotational flow. Aligned C60NWs could be transferred onto many different flat substrates, and, in this case, aligned C60NWs on glass substrates were employed as a scaffold for cell culture. Bone forming human osteoblast MG63 cells adhered well to the C60NWs, and their growth was found to be oriented with the axis of the aligned C60NWs. Cells grown on aligned C60NWs were more highly oriented with the axis of alignment than when grown on randomly oriented nanowhiskers. A study of cell proliferation on the C60NWs revealed their low toxicity, indicating their potential for use in biomedical applications.
巻・号 7(28)
ページ 15667-73
公開日 2015-7-22
DOI 10.1021/acsami.5b04811
PMID 26115554
MeSH Cell Adhesion Cell Line Cell Proliferation* Fullerenes / chemistry* Humans Nanostructures / chemistry* Osteoblasts / cytology* Polymers / chemical synthesis* Polymers / chemistry Tissue Engineering / instrumentation* Tissue Scaffolds / chemistry*
IF 8.758
リソース情報
ヒト・動物細胞 MG-63(RCB1890)