論文 - 詳細
| RRC ID | 67755 |
|---|---|
| 著者 | Miki K, Inoue T, Kobayashi Y, Nakano K, Matsuoka H, Yamauchi F, Yano T, Ohe K. |
| タイトル | Near-infrared dye-conjugated amphiphilic hyaluronic acid derivatives as a dual contrast agent for in vivo optical and photoacoustic tumor imaging. |
| ジャーナル | Biomacromolecules |
| Abstract |
Amphiphilic hyaluronic acid (HA) derivatives bearing hydrophobic indocyanine green dye derivatives and hydrophilic poly(ethylene glycol) were synthesized through the use of condensation and copper-catalyzed click cyclization reactions. The amphiphilic HA derivatives dissolved in water and formed self-assemblies in which the near-infrared dyes were tightly packed and arranged to form dimers or H-aggregates. By irradiating an aqueous solution of HA derivatives with near-infrared light, photoacoustic signals were detected along with fluorescence emission. Self-assemblies consisting of HA derivatives could smoothly accumulate in tumor tissues by passive tumor targeting. By utilizing HA derivatives as a contrast agent, tumor sites were clearly visualized by optical imaging as well as by photoacoustic tomography. |
| 巻・号 | 16(1) |
| ページ | 219-27 |
| 公開日 | 2015-1-12 |
| DOI | 10.1021/bm501438e |
| PMID | 25402751 |
| MeSH | Adjuvants, Immunologic / chemical synthesis Animals Cell Line, Tumor Colonic Neoplasms / pathology* Coloring Agents / chemistry Contrast Media* / chemical synthesis Hyaluronic Acid / analogs & derivatives* Indocyanine Green / chemistry Infrared Rays Mice Neoplasm Transplantation Photoacoustic Techniques Polyethylene Glycols / chemistry Tomography |
| IF | 6.092 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Colon-26(RCB2657) |