| RRC ID |
67755
|
| 著者 |
Miki K, Inoue T, Kobayashi Y, Nakano K, Matsuoka H, Yamauchi F, Yano T, Ohe K.
|
| タイトル |
Near-infrared dye-conjugated amphiphilic hyaluronic acid derivatives as a dual contrast agent for in vivo optical and photoacoustic tumor imaging.
|
| ジャーナル |
Biomacromolecules
|
| Abstract |
Amphiphilic hyaluronic acid (HA) derivatives bearing hydrophobic indocyanine green dye derivatives and hydrophilic poly(ethylene glycol) were synthesized through the use of condensation and copper-catalyzed click cyclization reactions. The amphiphilic HA derivatives dissolved in water and formed self-assemblies in which the near-infrared dyes were tightly packed and arranged to form dimers or H-aggregates. By irradiating an aqueous solution of HA derivatives with near-infrared light, photoacoustic signals were detected along with fluorescence emission. Self-assemblies consisting of HA derivatives could smoothly accumulate in tumor tissues by passive tumor targeting. By utilizing HA derivatives as a contrast agent, tumor sites were clearly visualized by optical imaging as well as by photoacoustic tomography.
|
| 巻・号 |
16(1)
|
| ページ |
219-27
|
| 公開日 |
2015-1-12
|
| DOI |
10.1021/bm501438e
|
| PMID |
25402751
|
| MeSH |
Adjuvants, Immunologic / chemical synthesis
Animals
Cell Line, Tumor
Colonic Neoplasms / pathology*
Coloring Agents / chemistry
Contrast Media* / chemical synthesis
Hyaluronic Acid / analogs & derivatives*
Indocyanine Green / chemistry
Infrared Rays
Mice
Neoplasm Transplantation
Photoacoustic Techniques
Polyethylene Glycols / chemistry
Tomography
|
| IF |
6.092
|
| リソース情報 |
| ヒト・動物細胞 |
Colon-26(RCB2657) |
