Reference - Detail
| RRC ID | 67762 |
|---|---|
| Author | Kitaoka Y, Miyazaki M, Kikuchi S. |
| Title | Voluntary exercise prevents abnormal muscle mitochondrial morphology in cancer cachexia mice. |
| Journal | Physiol Rep |
| Abstract |
This study aimed to examine the effects of voluntary wheel running on cancer cachexia-induced mitochondrial alterations in mouse skeletal muscle. Mice bearing colon 26 adenocarcinoma (C26) were used as a model of cancer cachexia. C26 mice showed a lower gastrocnemius and plantaris muscle weight, but 4 weeks of voluntary exercise rescued these changes. Further, voluntary exercise attenuated observed declines in the levels of oxidative phosphorylation proteins and activities of citrate synthase and cytochrome c oxidase in the skeletal muscle of C26 mice. Among mitochondrial morphology regulatory proteins, mitofusin 2 (Mfn2) and dynamin-related protein 1 (Drp1) were decreased in the skeletal muscle of C26 mice, but exercise resulted in similar improvements as seen in markers of mitochondrial content. In isolated mitochondria, 4-hydroxynonenal and protein carbonyls were elevated in C26 mice, but exercise blunted the increases in these markers of oxidative stress. In addition, electron microscopy revealed that exercise alleviated the observed increase in the percentage of damaged mitochondria in C26 mice. These results suggest that voluntary exercise effectively counteracts mitochondrial dysfunction to mitigate muscle loss in cachexia. |
| Volume | 9(16) |
| Pages | e15016 |
| Published | 2021-8-1 |
| DOI | 10.14814/phy2.15016 |
| PMID | 34427401 |
| PMC | PMC8383714 |
| MeSH | Animals Cachexia / etiology Cachexia / prevention & control* Citrate (si)-Synthase / metabolism Dynamins / metabolism Electron Transport Complex IV / metabolism GTP Phosphohydrolases / metabolism Male Mice Mitochondria, Muscle / metabolism Mitochondria, Muscle / ultrastructure* Motor Activity Muscle, Skeletal / metabolism Muscle, Skeletal / ultrastructure Neoplasms / complications* Oxidative Stress Physical Conditioning, Animal / methods* Protein Carbonylation |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 15 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | Colon-26(RCB2657) |