RRC ID 67794
著者 Yanagita K, Nagashio R, Ryuge S, Katono K, Jiang SX, Tsuchiya B, Nakashima H, Fukuda E, Goshima N, Saegusa M, Satoh Y, Masuda N, Sato Y.
タイトル Serum Anti-Gal-3 Autoantibody is a Predictive Marker of the Efficacy of Platinum-Based Chemotherapy against Pulmonary Adenocarcinoma.
ジャーナル Asian Pac J Cancer Prev
Abstract BACKGROUND:Identification of predictive markers for the efficacy of platinum-based chemotherapy is necessary to improve the quality of the life of cancer patients.
MATERIALS AND METHODS:We detected proteins recognized by autoantibodies in pretreated sera from patients with lung adenocarcinoma (AC) evaluated as showing progressive disease (PD) or a partial response (PR) after cisplatin-based chemotherapy by proteomic analysis. Then, the levels of the candidate autoantibodies in the pretreated serum were validated by dot-blot analysis for 22 AC patients who received platinum-based chemotherapy, and the expression of identified proteins was immunohistochemically analyzed in 40 AC biopsy specimens.
RESULTS:An autoantibody against galectin-3 (Gal-3) was detected in pretreated sera from an AC patient with PD. Serum IgG levels of anti-Gal-3 autoantibody were significantly higher in patients evaluated with PD than in those with PR and stable disease (SD) (p = 0.0084). Furthermore, pretreated biopsy specimens taken from patients evaluated as showing PD following platinum- based chemotherapy showed a tendency to have a higher positive rate of Gal-3 than those with PR and SD (p = 0.0601).
CONCLUSIONS:These results suggest that serum IgG levels of anti-Gal-3 autoantibody may be useful to predict the efficacy of platinum-based chemotherapy for patients with lung AC.
巻・号 16(17)
ページ 7959-65
公開日 2015-1-1
DOI 10.7314/apjcp.2015.16.17.7959
PMID 26625826
MeSH Adenocarcinoma / drug therapy* Adenocarcinoma of Lung Antineoplastic Agents / therapeutic use* Autoantibodies / blood* Autoantibodies / immunology* Biomarkers, Tumor / blood Biomarkers, Tumor / immunology Blood Proteins Cell Line, Tumor Cisplatin / therapeutic use* Galectin 3 / immunology* Galectins Humans Immunoglobulin G / blood Immunoglobulin G / immunology Lung Neoplasms / drug therapy* Quality of Life Treatment Outcome
リソース情報
ヒト・動物細胞 LC-2/ad(RCB0440)