論文 - 詳細
RRC ID | 67794 |
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著者 | Yanagita K, Nagashio R, Ryuge S, Katono K, Jiang SX, Tsuchiya B, Nakashima H, Fukuda E, Goshima N, Saegusa M, Satoh Y, Masuda N, Sato Y. |
タイトル | Serum Anti-Gal-3 Autoantibody is a Predictive Marker of the Efficacy of Platinum-Based Chemotherapy against Pulmonary Adenocarcinoma. |
ジャーナル | Asian Pac J Cancer Prev |
Abstract |
BACKGROUND:Identification of predictive markers for the efficacy of platinum-based chemotherapy is necessary to improve the quality of the life of cancer patients. MATERIALS AND METHODS:We detected proteins recognized by autoantibodies in pretreated sera from patients with lung adenocarcinoma (AC) evaluated as showing progressive disease (PD) or a partial response (PR) after cisplatin-based chemotherapy by proteomic analysis. Then, the levels of the candidate autoantibodies in the pretreated serum were validated by dot-blot analysis for 22 AC patients who received platinum-based chemotherapy, and the expression of identified proteins was immunohistochemically analyzed in 40 AC biopsy specimens. RESULTS:An autoantibody against galectin-3 (Gal-3) was detected in pretreated sera from an AC patient with PD. Serum IgG levels of anti-Gal-3 autoantibody were significantly higher in patients evaluated with PD than in those with PR and stable disease (SD) (p = 0.0084). Furthermore, pretreated biopsy specimens taken from patients evaluated as showing PD following platinum- based chemotherapy showed a tendency to have a higher positive rate of Gal-3 than those with PR and SD (p = 0.0601). CONCLUSIONS:These results suggest that serum IgG levels of anti-Gal-3 autoantibody may be useful to predict the efficacy of platinum-based chemotherapy for patients with lung AC. |
巻・号 | 16(17) |
ページ | 7959-65 |
公開日 | 2015-1-1 |
DOI | 10.7314/apjcp.2015.16.17.7959 |
PMID | 26625826 |
MeSH | Adenocarcinoma / drug therapy* Adenocarcinoma of Lung Antineoplastic Agents / therapeutic use* Autoantibodies / blood* Autoantibodies / immunology* Biomarkers, Tumor / blood Biomarkers, Tumor / immunology Blood Proteins Cell Line, Tumor Cisplatin / therapeutic use* Galectin 3 / immunology* Galectins Humans Immunoglobulin G / blood Immunoglobulin G / immunology Lung Neoplasms / drug therapy* Quality of Life Treatment Outcome |
リソース情報 | |
ヒト・動物細胞 | LC-2/ad(RCB0440) |