RRC ID 67814
Author Murakami K, Hata S, Ishibashi N, Kubota M, Eishi Y, Uchida K, Tabata T, Nakamura Y, Murakami K.
Title A Solitary Necrotizing Sarcoid Granulomatosis-like Pulmonary Lesion Possibly Associated with Propionibacterium Acnes and Mycobacterium Avium.
Journal Intern Med
Abstract We report a case of a pulmonary necrotizing sarcoid granulomatosis (NSG)-like lesion possibly associated with coinfection of Mycobacterium avium and Propionibacterium acnes. A solitary nodule in the right middle lobe of the lung was notable for coagulative necrosis with aggregates of sarcoid-like epithelioid granulomas. Small arteries were damaged by granulomas. Both M. avium and P. acnes were detected in the lesion. Furthermore, more P. acnes genomes were detected in the granulomas than in the non-lesion lung. These findings blur the pathophysiologic boundaries among NSG, sarcoidosis, and mycobacteriosis, and suggest that NSG needs to be recognized as continuous spectra of sarcoidosis/mycobcteriosis.
Published 2021-6-12
DOI 10.2169/internalmedicine.7162-21
PMID 34121004
IF 0.956
Resource
DNA material Genomic DNA of Cutibacterium acnes subsp. acnes JCM 6425 T (JGD07462)