論文 - 詳細
| RRC ID | 67823 |
|---|---|
| 著者 | Johnston RJ Jr, Otake Y, Sood P, Vogt N, Behnia R, Vasiliauskas D, McDonald E, Xie B, Koenig S, Wolf R, Cook T, Gebelein B, Kussell E, Nakagoshi H, Desplan C. |
| タイトル | Interlocked feedforward loops control cell-type-specific Rhodopsin expression in the Drosophila eye. |
| ジャーナル | Cell |
| Abstract |
How complex networks of activators and repressors lead to exquisitely specific cell-type determination during development is poorly understood. In the Drosophila eye, expression patterns of Rhodopsins define at least eight functionally distinct though related subtypes of photoreceptors. Here, we describe a role for the transcription factor gene defective proventriculus (dve) as a critical node in the network regulating Rhodopsin expression. dve is a shared component of two opposing, interlocked feedforward loops (FFLs). Orthodenticle and Dve interact in an incoherent FFL to repress Rhodopsin expression throughout the eye. In R7 and R8 photoreceptors, a coherent FFL relieves repression by Dve while activating Rhodopsin expression. Therefore, this network uses repression to restrict and combinatorial activation to induce cell-type-specific expression. Furthermore, Dve levels are finely tuned to yield cell-type- and region-specific repression or activation outcomes. This interlocked FFL motif may be a general mechanism to control terminal cell-fate specification. |
| 巻・号 | 145(6) |
| ページ | 956-68 |
| 公開日 | 2011-6-10 |
| DOI | 10.1016/j.cell.2011.05.003 |
| PII | S0092-8674(11)00529-0 |
| PMID | 21663797 |
| PMC | PMC3117217 |
| MeSH | Animals Drosophila / cytology Drosophila / embryology* Drosophila / metabolism* Drosophila Proteins / genetics* Drosophila Proteins / metabolism Eye / embryology Feedback, Physiological Gene Expression Regulation, Developmental* Gene Regulatory Networks* Homeodomain Proteins / metabolism Photoreceptor Cells, Invertebrate / metabolism* Rhodopsin / genetics* Transcription Factors / metabolism |
| IF | 38.637 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ショウジョウバエ | |