論文 - 詳細
| RRC ID | 67838 |
|---|---|
| 著者 | Yoshida H, Tsuhako R, Sugita C, Kurokawa M. |
| タイトル | Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Glucosyl hesperidin (GH) is a water-soluble derivative of hesperidin, a citrus flavonoid. GH has various pharmacological effects, such as hypolipidemic and hypouricemic effects, and may therefore be a useful supplement or drug. In the present study, we evaluated the effects of long- and short-term intake of GH on hyperglycemia and macrophage infiltration into the adipose tissue of high-fat diet (HFD)-fed mice. Long-term (11-week) consumption of GH tended to reduce body weight and the fasting blood glucose concentration of the HFD-fed mice, and ameliorated glucose intolerance and insulin resistance, according to glucose and insulin tolerance tests. Additionally, although GH did not affect fat pad weight, it reduced HFD-induced macrophage infiltration into adipose tissue. Short-term (2-week) consumption of GH did not affect the HFD-induced increases in body weight or fasting blood glucose, and it did not ameliorate glucose intolerance or insulin resistance. However, short-term intake did reduce the HFD-induced macrophage infiltration and monocyte chemotactic protein 1 (MCP-1) expression in adipose tissue. Furthermore, hesperetin, which is an aglycone of GH, inhibited MCP-1 expression in 3T3-L1 adipocytes, 3T3-L1 adipocytes co-cultured with RAW264 macrophages, and tumor necrosis factor-α-treated 3T3-L1 adipocytes. The present findings suggest that daily consumption of GH may have preventive and/or therapeutic effects on obesity-related diseases, such as diabetes mellitus. |
| 巻・号 | 44(3) |
| ページ | 422-430 |
| 公開日 | 2021-1-1 |
| DOI | 10.1248/bpb.b20-00849 |
| PMID | 33642550 |
| MeSH | 3T3-L1 Cells Adipose Tissue / drug effects Adipose Tissue / immunology Animals Chemokine CCL2 / genetics Chemokine CCL2 / immunology Coculture Techniques Diet, High-Fat Disease Models, Animal Glucosides / pharmacology Glucosides / therapeutic use* Hesperidin / analogs & derivatives* Hesperidin / pharmacology Hesperidin / therapeutic use Hyperglycemia / drug therapy* Hyperglycemia / immunology Hypoglycemic Agents / pharmacology Hypoglycemic Agents / therapeutic use* Macrophages / drug effects Macrophages / immunology Male Mice Mice, Inbred C57BL Obesity / drug therapy* Obesity / immunology RAW 264.7 Cells |
| IF | 1.863 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |