Reference - Detail
RRC ID | 67933 |
---|---|
Author | Aoyagi Y, Adachi Y, Ozawa K, Yokomizo C, Gui MY, Jin YR, Li XW, Ohno N, Takeya K. |
Title | Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation. |
Journal | Bioorg Med Chem |
Abstract |
A series of rabdokunmin C analogues were prepared and their inhibitory effect on NF-κB activation was assayed. One of them, 18-acetyl-12-deoxy-11,12-dehydrorabdokunmin C (16) was found to be a promising candidate for an anti-inflammatory agent. |
Volume | 19(7) |
Pages | 2450-7 |
Published | 2011-4-1 |
DOI | 10.1016/j.bmc.2011.02.002 |
PII | S0968-0896(11)00098-8 |
PMID | 21393004 |
MeSH | Animals Diterpenes / chemical synthesis* Diterpenes / pharmacology* Diterpenes, Kaurane / chemical synthesis Diterpenes, Kaurane / pharmacology Hep G2 Cells Humans Leukemia P388 / drug therapy Macrophages / drug effects Mice NF-kappa B / genetics NF-kappa B / metabolism* Structure-Activity Relationship |
IF | 3.073 |
Resource | |
Human and Animal Cells | RAW 264(RCB0535) |