Reference - Detail
| RRC ID | 67981 |
|---|---|
| Author | Ohata T, Fukuda K, Takahashi M, Sugimura T, Wakabayashi K. |
| Title | Suppression of nitric oxide production in lipopolysaccharide-stimulated macrophage cells by omega 3 polyunsaturated fatty acids. |
| Journal | Jpn J Cancer Res |
| Abstract |
Although nitric oxide (NO) is an important biological mediator, its excessive production in inflammation is thought to be a causative factor for cellular injury and, over the long term, cancer. In the present study, the effects of several fatty acids on NO production in murine macrophage cell line RAW264 cells stimulated with lipopolysaccharide were examined. Suppression of NO production was observed with the omega 3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid, in a dose-dependent fashion. In contrast, no inhibition was observed with omega 6 PUFA (linoleic acid), omega 9 PUFA (oleic acid) or a saturated fatty acid (stearic acid). Western and northern blot analyses suggested that suppression of the induction of inducible NO synthase gene expression is responsible for the inhibition of NO production by omega 3 PUFAs. The inhibitory effect of omega 3 PUFA on NO production in activated macrophages could contribute to their cancer chemopreventive influence. |
| Volume | 88(3) |
| Pages | 234-7 |
| Published | 1997-3-1 |
| DOI | 10.1111/j.1349-7006.1997.tb00372.x |
| PII | S0910505097841130 |
| PMID | 9140106 |
| PMC | PMC5921376 |
| MeSH | Animals Cell Line Docosahexaenoic Acids / pharmacology Eicosapentaenoic Acid / pharmacology Fatty Acids, Omega-3 / pharmacology* Kinetics Linoleic Acid Linoleic Acids / pharmacology Lipopolysaccharides / pharmacology* Macrophages / drug effects* Macrophages / enzymology Mice Nitric Oxide / biosynthesis Nitric Oxide Synthase / antagonists & inhibitors Nitric Oxide Synthase / biosynthesis* Oleic Acid / pharmacology alpha-Linolenic Acid / pharmacology |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |