論文 - 詳細
| RRC ID | 68071 |
|---|---|
| 著者 | Sun T, Song Y, Teng D, Chen Y, Dai J, Ma M, Zhang W, Pastor-Pareja JC. |
| タイトル | Atypical laminin spots and pull-generated microtubule-actin projections mediate Drosophila wing adhesion. |
| ジャーナル | Cell Rep |
| Abstract |
During Drosophila metamorphosis, dorsal and ventral wing surfaces adhere, separate, and reappose in a paradoxical process involving cell-matrix adhesion, matrix production and degradation, and long cellular projections. The identity of the intervening matrix, the logic behind the adhesion-reapposition cycle, and the role of projections are unknown. We find that laminin matrix spots devoid of other main basement membrane components mediate wing adhesion. Through live imaging, we show that long microtubule-actin cables grow from those adhesion spots because of hydrostatic pressure that pushes wing surfaces apart. Formation of cables resistant to pressure requires spectraplakin, Patronin, septins, and Sdb, a SAXO1/2 microtubule stabilizer expressed under control of wing intervein-selector SRF. Silkworms and dead-leaf butterflies display similar dorso-ventral projections and expression of Sdb in intervein SRF-like patterns. Our study supports the morphogenetic importance of atypical basement-membrane-related matrices and dissects matrix-cytoskeleton coordination in a process of great evolutionary significance. |
| 巻・号 | 36(10) |
| ページ | 109667 |
| 公開日 | 2021-9-7 |
| DOI | 10.1016/j.celrep.2021.109667 |
| PII | S2211-1247(21)01111-6 |
| PMID | 34496252 |
| MeSH | Actins / metabolism* Animals Basement Membrane / metabolism Butterflies / metabolism Drosophila / metabolism Drosophila Proteins / metabolism Laminin / metabolism* Metamorphosis, Biological / physiology Microtubule-Associated Proteins / metabolism Microtubules / metabolism* Morphogenesis / physiology Wings, Animal / metabolism* |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 1560R-1 16858R-3 1403R-1 2916R-1 |