| RRC ID |
68078
|
| 著者 |
Ouchi S, Niiyama E, Sugo K, Uto K, Takenaka S, Kikuchi A, Ebara M.
|
| タイトル |
Shape-memory balloon offering simultaneous thermo/chemotherapies to improve anti-osteosarcoma efficacy.
|
| ジャーナル |
Biomater Sci
|
| Abstract |
This paper proposes a shape-memory balloon (SMB) to improve bone cement injection efficiency and postoperative thermo/chemotherapy for bone tumors. The SMB consists of biodegradable poly(ε-caprolactone) (PCL), an anticancer drug (doxorubicin, DOX), and heat-generating magnetic nanoparticles (MNPs). The balloon shape is fabricated in a mold by crosslinking PCL macromonomers with DOX and MNPs. The mechanical properties and shape-transition temperature (approximately 40 °C) of the SMB are modulated by adjusting the molecular weight of PCL and the crosslinking density. This allows safe inflation at the affected site with a 400% expansion rate by simple blow molding. The expanded shape is temporarily memorized at 37 °C, and the computed tomography image shows that the bone cement is successfully injected without extra pressure or leakage. The SMB releases DOX for over 4 weeks, allowing a prolonged effect at the local site. The local dosing is constant as the medication is continuously released, demonstrating an ON-OFF switchable heating/cooling response to alternating magnetic field irradiation. In vitro cytotoxic studies have demonstrated that heat generation/drug release and only drug release from the balloon kill approximately 99% and 60% of human osteosarcoma cells, respectively. The proposed SMB is promising in postoperative local thermo/chemotherapy for bone tumors.
|
| 巻・号 |
9(20)
|
| ページ |
6957-6965
|
| 公開日 |
2021-10-12
|
| DOI |
10.1039/d1bm00780g
|
| PMID |
34546257
|
| MeSH |
Doxorubicin
Drug Carriers
Humans
Micelles
Osteosarcoma* / drug therapy
Polyesters*
|
| IF |
6.183
|
| リソース情報 |
| ヒト・動物細胞 |
HOS(RCB0992) |
