論文 - 詳細
| RRC ID | 6809 |
|---|---|
| 著者 | Furuta T, Kimura M, Watanabe N. |
| タイトル | Elevated levels of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor (VEGFR)-2 in human malaria. |
| ジャーナル | Am J Trop Med Hyg |
| Abstract |
In cerebral malaria, the binding of parasitized erythrocytes to the cerebral endothelium and the consequent angiogenic dysregulation play a key role in pathogenesis. Because vascular endothelial growth factor (VEGF) is widely regarded as a potent stimulator of angiogenesis, edema, inflammation, and vascular remodeling, the plasma levels of VEGF and the soluble form of the VEGF receptor (sVEGFR)-1 and -2 in uncomplicated malaria patients and healthy adults were measured by enzyme-linked immunosorbent assay (ELISA) to examine their roles in malaria. The results showed that VEGF and sVEGFR-2 levels were significantly elevated in malaria patients compared with healthy adults. Moreover, it was confirmed that malarial parasite antigens induced VEGF secretion from the human mast cell lines HMC-1 or KU812 cell. This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells. |
| 巻・号 | 82(1) |
| ページ | 136-9 |
| 公開日 | 2010-1-1 |
| DOI | 10.4269/ajtmh.2010.09-0203 |
| PII | 82/1/136 |
| PMID | 20065009 |
| PMC | PMC2803523 |
| MeSH | Adult Case-Control Studies Enzyme-Linked Immunosorbent Assay Humans Malaria / metabolism* Vascular Endothelial Growth Factor A / metabolism* Vascular Endothelial Growth Factor Receptor-2 / metabolism* |
| IF | 2.126 |
| 引用数 | 16 |
| WOS 分野 | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH TROPICAL MEDICINE |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | |