RRC ID 6809
著者 Furuta T, Kimura M, Watanabe N.
タイトル Elevated levels of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor (VEGFR)-2 in human malaria.
ジャーナル Am J Trop Med Hyg
Abstract In cerebral malaria, the binding of parasitized erythrocytes to the cerebral endothelium and the consequent angiogenic dysregulation play a key role in pathogenesis. Because vascular endothelial growth factor (VEGF) is widely regarded as a potent stimulator of angiogenesis, edema, inflammation, and vascular remodeling, the plasma levels of VEGF and the soluble form of the VEGF receptor (sVEGFR)-1 and -2 in uncomplicated malaria patients and healthy adults were measured by enzyme-linked immunosorbent assay (ELISA) to examine their roles in malaria. The results showed that VEGF and sVEGFR-2 levels were significantly elevated in malaria patients compared with healthy adults. Moreover, it was confirmed that malarial parasite antigens induced VEGF secretion from the human mast cell lines HMC-1 or KU812 cell. This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells.
巻・号 82(1)
ページ 136-9
公開日 2010-1-1
DOI 10.4269/ajtmh.2010.09-0203
PII 82/1/136
PMID 20065009
PMC PMC2803523
MeSH Adult Case-Control Studies Enzyme-Linked Immunosorbent Assay Humans Malaria / metabolism* Vascular Endothelial Growth Factor A / metabolism* Vascular Endothelial Growth Factor Receptor-2 / metabolism*
IF 2.126
引用数 16
WOS 分野 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH TROPICAL MEDICINE
リソース情報
ヒト・動物細胞