RRC ID |
6809
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著者 |
Furuta T, Kimura M, Watanabe N.
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タイトル |
Elevated levels of vascular endothelial growth factor (VEGF) and soluble vascular endothelial growth factor receptor (VEGFR)-2 in human malaria.
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ジャーナル |
Am J Trop Med Hyg
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Abstract |
In cerebral malaria, the binding of parasitized erythrocytes to the cerebral endothelium and the consequent angiogenic dysregulation play a key role in pathogenesis. Because vascular endothelial growth factor (VEGF) is widely regarded as a potent stimulator of angiogenesis, edema, inflammation, and vascular remodeling, the plasma levels of VEGF and the soluble form of the VEGF receptor (sVEGFR)-1 and -2 in uncomplicated malaria patients and healthy adults were measured by enzyme-linked immunosorbent assay (ELISA) to examine their roles in malaria. The results showed that VEGF and sVEGFR-2 levels were significantly elevated in malaria patients compared with healthy adults. Moreover, it was confirmed that malarial parasite antigens induced VEGF secretion from the human mast cell lines HMC-1 or KU812 cell. This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells.
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巻・号 |
82(1)
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ページ |
136-9
|
公開日 |
2010-1-1
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DOI |
10.4269/ajtmh.2010.09-0203
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PII |
82/1/136
|
PMID |
20065009
|
PMC |
PMC2803523
|
MeSH |
Adult
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Humans
Malaria / metabolism*
Vascular Endothelial Growth Factor A / metabolism*
Vascular Endothelial Growth Factor Receptor-2 / metabolism*
|
IF |
2.126
|
引用数 |
16
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WOS 分野
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PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
TROPICAL MEDICINE
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リソース情報 |
ヒト・動物細胞 |
|