| RRC ID |
68146
|
| 著者 |
Yu BS, Sung YJ, Choi HI, Sirohi R, Sim SJ.
|
| タイトル |
Concurrent enhancement of CO2 fixation and productivities of omega-3 fatty acids and astaxanthin in Haematococcus pluvialis culture via calcium-mediated homeoviscous adaptation and biomineralization.
|
| ジャーナル |
Bioresour Technol
|
| Abstract |
Haematococcus pluvialis has attracted interest as a bio-platform for producing omega-3 fatty acids (ω-3 FA) and astaxanthin that have a great potential as anti-inflammatory drugs. This study aimed to concurrently enhance the CO2 fixation and the productivities of ω-3 FA and astaxanthin, which have been difficult to achieve because of the dissimilar culture methods for each goal, via calcium-mediated homeoviscous adaptation and biomineralization. As a result of 3 mM of Ca2+ addition, ω-3 FA content was improved by 31% due to Ca2+-induced homeoviscous adaptation. Biomineralization was promoted by the extracellular carbonic anhydrase, which resulted in 46.3% improvement in CO2 fixation. CaCO3 from the biomineralization was beneficially re-used in the H. pluvialis culture and triggered 178- and 522-fold increased biomass productivity and astaxanthin content, respectively, thanks to its anisotropic nature. The Ca2+-based productivity enhancement strategy was applied to large-scale culture which resulted improvement in overall bioprocess performance.
|
| 巻・号 |
340
|
| ページ |
125720
|
| 公開日 |
2021-11-1
|
| DOI |
10.1016/j.biortech.2021.125720
|
| PII |
S0960-8524(21)01061-0
|
| PMID |
34365300
|
| MeSH |
Biomineralization
Calcium
Carbon Dioxide*
Fatty Acids, Omega-3*
Xanthophylls
|
| IF |
7.539
|
| リソース情報 |
| 藻類 |
NIES-144 |
