論文 - 詳細
| RRC ID | 68490 |
|---|---|
| 著者 | Kimura K, Yamamoto M. |
| タイトル | Rapid induction of Fas antigen mRNA expression in vivo by cycloheximide. |
| ジャーナル | Cell Biochem Funct |
| Abstract |
The effect of administration into rats of cycloheximide on the expression of genes, such as tissue transglutaminase, testosterone-repressed prostate message-2, Fas antigen, bcl-2, DNase I, and poly(ADP-ribose) polymerase, which were believed to be involved in the mechanism of apoptosis, was studied. While the effect of cycloheximide on the expression of genes other than Fas antigen was modest, only the expression of Fas antigen was elevated rapidly in most of the organs examined. A possible direct effect of cycloheximide on cells per se to induce Fas antigen mRNA expression was demonstrated by the tissue culture study using L929 fibroblast cells, although the magnitude of the induction detected in vitro was small compared with that in vivo. This induction of Fas antigen mRNA by cycloheximide is a first report on the modulation of Fas antigen mRNA expression in vivo. |
| 巻・号 | 15(2) |
| ページ | 81-6 |
| 公開日 | 1997-6-1 |
| DOI | 10.1002/(SICI)1099-0844(19970601)15:2<81::AID-CBF722>3.0.CO;2-# |
| PII | 10.1002/(SICI)1099-0844(19970601)15:2<81::AID-CBF722>3.0.CO;2-# |
| PMID | 9253159 |
| MeSH | Animals Apoptosis / drug effects Cell Line Clusterin Cycloheximide / pharmacology* Deoxyribonuclease I / biosynthesis Deoxyribonuclease I / drug effects Deoxyribonuclease I / genetics Gene Expression Regulation / drug effects Gene Expression Regulation / genetics Glycoproteins / biosynthesis Glycoproteins / drug effects Glycoproteins / genetics Lipopolysaccharides / pharmacology Male Mice Molecular Chaperones* Poly(ADP-ribose) Polymerases / biosynthesis Poly(ADP-ribose) Polymerases / drug effects Poly(ADP-ribose) Polymerases / genetics Proto-Oncogene Proteins c-bcl-2 / biosynthesis Proto-Oncogene Proteins c-bcl-2 / drug effects Proto-Oncogene Proteins c-bcl-2 / genetics RNA, Messenger / biosynthesis* RNA, Messenger / drug effects* Rats Rats, Sprague-Dawley Transglutaminases / biosynthesis Transglutaminases / drug effects Transglutaminases / genetics fas Receptor / biosynthesis fas Receptor / drug effects fas Receptor / genetics* |
| IF | 2.632 |
| リソース情報 | |
| ヒト・動物細胞 | L929(RCB0081) |