Reference - Detail
| RRC ID | 68553 |
|---|---|
| Author | Akihisa T, Seino K, Kaneko E, Watanabe K, Tochizawa S, Fukatsu M, Banno N, Metori K, Kimura Y. |
| Title | Melanogenesis inhibitory activities of iridoid-, hemiterpene-, and fatty acid-glycosides from the fruits of Morinda citrifolia (Noni). |
| Journal | J Oleo Sci |
| Abstract |
A new iridoid glycoside, 9-epi-6alpha-methoxy geniposidic acid (4), three new hemiterpene glycosides, 3-methylbut-3-enyl 2'-O-(beta-D-glucopyranosyl)-beta-D-glucopyranoside (nonioside K) (6), 3-methylbut-3-enyl 6'-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside (nonioside L) (8), and 3-methylbut-3-enyl 6'-O-(beta-D-xylofuranosyl)-beta-D-glucopyranoside (nonioside M) (9), and two new saccharide fatty acid esters, 6'-O-(beta-D-glucopyranosyl)-1'-O-[(2xi)-2-methylbutanoyl]-beta-D-glucopyranose (nonioside N) (16) and 6'-O-(beta-D-xylopyranosyl)-1'-O-[(2xi)-2-methylbutanoyl]-beta-D-glucopyranose (nonioside O) (17), were isolated from a methanol extract of the fruits of Morinda citrifolia (noni), along with 11 known compounds, namely, three iridoid glycosides (1-3), two hemiterpene glycosides (5 and 7), and five saccharide fatty acid esters (10-15). Upon evaluation of compounds 1-17 on the melanogenesis in the B16 melanoma cells induced with alpha-melanocyte-stimulating hormone (alpha-MSH), 13 compounds (1, 3, 4, 6-14, and 17) exhibited marked inhibitory effects with 34-49% reduction of melanin content at 100 muM with no or almost no toxicity to the cells (91-116% of cell viability at 100 microM). |
| Volume | 59(1) |
| Pages | 49-57 |
| Published | 2010-1-1 |
| DOI | 10.5650/jos.59.49 |
| PII | JST.JSTAGE/jos/59.49 |
| PMID | 20032599 |
| MeSH | Antineoplastic Agents* / chemistry Antineoplastic Agents* / pharmacology Cell Line, Tumor Fatty Acids / chemistry* Fatty Acids / pharmacology Fruit / chemistry* Glycosides / chemistry* Glycosides / pharmacology Humans Iridoids / chemistry* Iridoids / pharmacology Melanins / antagonists & inhibitors* Molecular Structure Morinda / chemistry* Phytotherapy Pigmentation / drug effects Plant Preparations Terpenes / chemistry* Terpenes / pharmacology |
| IF | 1.304 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) |