論文 - 詳細
| RRC ID | 68609 |
|---|---|
| 著者 | Wang J, Zhang H, Kaul A, Li K, Priyandoko D, Kaul SC, Wadhwa R. |
| タイトル | Effect of Ashwagandha Withanolides on Muscle Cell Differentiation. |
| ジャーナル | Biomolecules |
| Abstract |
Withania somnifera (Ashwagandha) is used in Indian traditional medicine, Ayurveda, and is believed to have a variety of health-promoting effects. The molecular mechanisms and pathways underlying these effects have not yet been sufficiently explored. In this study, we investigated the effect of Ashwagandha extracts and their major withanolides (withaferin A and withanone) on muscle cell differentiation using C2C12 myoblasts. We found that withaferin A and withanone and Ashwagandha extracts possessing different ratios of these active ingredients have different effects on the differentiation of C2C12. Withanone and withanone-rich extracts caused stronger differentiation of myoblasts to myotubes, deaggregation of heat- and metal-stress-induced aggregated proteins, and activation of hypoxia and autophagy pathways. Of note, the Parkinson's disease model of Drosophila that possess a neuromuscular disorder showed improvement in their flight and climbing activity, suggesting the potential of Ashwagandha withanolides for the management of muscle repair and activity. |
| 巻・号 | 11(10) |
| 公開日 | 2021-10-4 |
| DOI | 10.3390/biom11101454 |
| PII | biom11101454 |
| PMID | 34680087 |
| PMC | PMC8533065 |
| MeSH | Animals Cell Differentiation / drug effects* Cell Line Humans Medicine, Ayurvedic / trends Mice Muscle Cells / drug effects Parkinson Disease / drug therapy Parkinson Disease / pathology Plant Extracts / chemistry* Plant Extracts / pharmacology Withanolides / chemistry Withanolides / pharmacology* |
| IF | 4.082 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | C2C12(RCB0987) |