論文 - 詳細
| RRC ID | 68621 |
|---|---|
| 著者 | Ostalé CM, Esteban N, López-Varea A, de Celis JF. |
| タイトル | Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing. |
| ジャーナル | G3 (Bethesda) |
| Abstract |
Protein kinases and phosphatases constitute a large family of conserved enzymes that control a variety of biological processes by regulating the phosphorylation state of target proteins. They play fundamental regulatory roles during cell cycle progression and signaling, among other key aspects of multicellular development. The complement of protein kinases and phosphatases includes approximately 326 members in Drosophila, and they have been the subject of several functional screens searching for novel components of signaling pathways and regulators of cell division and survival. These approaches have been carried out mostly in cell cultures using RNA interference to evaluate the contribution of each protein in different functional assays, and have contributed significantly to assign specific roles to the corresponding genes. In this work we describe the results of an evaluation of the Drosophila complement of kinases and phosphatases using the wing as a system to identify their functional requirements in vivo. We also describe the results of several modifying screens aiming to identify among the set of protein kinases and phosphatases additional components or regulators of the activities of the Epidermal Growth Factor and Insulin receptors signaling pathways. |
| 巻・号 | 11(12) |
| 公開日 | 2021-12-8 |
| DOI | 10.1093/g3journal/jkab348 |
| PII | 6380433 |
| PMID | 34599799 |
| PMC | PMC8664455 |
| MeSH | Animals Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / metabolism Phosphoric Monoester Hydrolases Protein Kinases / genetics RNA Interference Wings, Animal / metabolism |
| IF | 2.781 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 10539R-3 4012R-2 5092R-2 9738R-1 1891R-3 7904R-2 10079R-2 7525R-2 |