RRC ID 68688
Author Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, Yoshida Y, Maekawa T, Venugopal K, Kumar DS.
Title Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease.
Journal PLoS One
Abstract Alzheimer's disease is a growing concern in the modern world. As the currently available medications are not very promising, there is an increased need for the fabrication of newer drugs. Curcumin is a plant derived compound which has potential activities beneficial for the treatment of Alzheimer's disease. Anti-amyloid activity and anti-oxidant activity of curcumin is highly beneficial for the treatment of Alzheimer's disease. The insolubility of curcumin in water restricts its use to a great extend, which can be overcome by the synthesis of curcumin nanoparticles. In our work, we have successfully synthesized water-soluble PLGA coated- curcumin nanoparticles and characterized it using different techniques. As drug targeting to diseases of cerebral origin are difficult due to the stringency of blood-brain barrier, we have coupled the nanoparticle with Tet-1 peptide, which has the affinity to neurons and possess retrograde transportation properties. Our results suggest that curcumin encapsulated-PLGA nanoparticles are able to destroy amyloid aggregates, exhibit anti-oxidative property and are non-cytotoxic. The encapsulation of the curcumin in PLGA does not destroy its inherent properties and so, the PLGA-curcumin nanoparticles can be used as a drug with multiple functions in treating Alzheimer's disease proving it to be a potential therapeutic tool against this dreaded disease.
Volume 7(3)
Pages e32616
Published 2012-1-1
DOI 10.1371/journal.pone.0032616
PII PONE-D-11-19075
PMID 22403681
PMC PMC3293842
MeSH Alzheimer Disease / drug therapy* Amyloid / chemistry Animals Antioxidants / chemistry Antioxidants / metabolism Antioxidants / pharmacology Antioxidants / therapeutic use Biological Transport Cell Line, Tumor Curcumin / chemistry* Curcumin / metabolism Curcumin / pharmacology* Curcumin / therapeutic use Lactic Acid / chemistry* Mice Molecular Imaging Nanoconjugates / chemistry* Nanoconjugates / toxicity Nanoparticles / chemistry* Peptide Fragments / chemistry* Polyglycolic Acid / chemistry* Polylactic Acid-Polyglycolic Acid Copolymer Protein Multimerization / drug effects Protein Structure, Secondary
IF 2.74
Human and Animal Cells LAG(RCB2758)