RRC ID |
68688
|
著者 |
Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, Yoshida Y, Maekawa T, Venugopal K, Kumar DS.
|
タイトル |
Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease.
|
ジャーナル |
PLoS One
|
Abstract |
Alzheimer's disease is a growing concern in the modern world. As the currently available medications are not very promising, there is an increased need for the fabrication of newer drugs. Curcumin is a plant derived compound which has potential activities beneficial for the treatment of Alzheimer's disease. Anti-amyloid activity and anti-oxidant activity of curcumin is highly beneficial for the treatment of Alzheimer's disease. The insolubility of curcumin in water restricts its use to a great extend, which can be overcome by the synthesis of curcumin nanoparticles. In our work, we have successfully synthesized water-soluble PLGA coated- curcumin nanoparticles and characterized it using different techniques. As drug targeting to diseases of cerebral origin are difficult due to the stringency of blood-brain barrier, we have coupled the nanoparticle with Tet-1 peptide, which has the affinity to neurons and possess retrograde transportation properties. Our results suggest that curcumin encapsulated-PLGA nanoparticles are able to destroy amyloid aggregates, exhibit anti-oxidative property and are non-cytotoxic. The encapsulation of the curcumin in PLGA does not destroy its inherent properties and so, the PLGA-curcumin nanoparticles can be used as a drug with multiple functions in treating Alzheimer's disease proving it to be a potential therapeutic tool against this dreaded disease.
|
巻・号 |
7(3)
|
ページ |
e32616
|
公開日 |
2012-1-1
|
DOI |
10.1371/journal.pone.0032616
|
PII |
PONE-D-11-19075
|
PMID |
22403681
|
PMC |
PMC3293842
|
MeSH |
Alzheimer Disease / drug therapy*
Amyloid / chemistry
Animals
Antioxidants / chemistry
Antioxidants / metabolism
Antioxidants / pharmacology
Antioxidants / therapeutic use
Biological Transport
Cell Line, Tumor
Curcumin / chemistry*
Curcumin / metabolism
Curcumin / pharmacology*
Curcumin / therapeutic use
Lactic Acid / chemistry*
Mice
Molecular Imaging
Nanoconjugates / chemistry*
Nanoconjugates / toxicity
Nanoparticles / chemistry*
Peptide Fragments / chemistry*
Polyglycolic Acid / chemistry*
Polylactic Acid-Polyglycolic Acid Copolymer
Protein Multimerization / drug effects
Protein Structure, Secondary
|
IF |
2.74
|
リソース情報 |
ヒト・動物細胞 |
LAG(RCB2758) |