RRC ID 68818
Author Kawakami Y, Nomura K, Tanaka H.
Title Growth promoting effect of hyaluronan synthesis promoting substances on Japanese eel leptocephali.
Journal PLoS One
Abstract Hyaluronans (HAs) are glycosaminoglycans produced in the bodies of Anguilliform and Elopiform leptocephali, and play a role in metabolic energy. In mammals, HA synthesis-promoting substances (HASPS) up-regulate the expression of HA synthase (HAS) and increase the amount of HA in the body. In this study, Japanese eel leptocephali were fed a HASPS containing diet. We analyzed HAS1s and HAS2 expression, HA content, and their influence on growth. HASPS extracted from Grifola frondosa promoted HAS1s and HAS2 mRNA and HA content. Other than mammals, these results are first reported in vertebrate. Moreover, HASPS extracted from G. frondosa promoted leptocephalus growth. The relationship between growth and HA in the leptocephali is not yet clear. However, based on our results we hypothesize that HA is involved in the storage of energy, which is metabolized to sugars when needed for metabolic energy.
Volume 9(6)
Pages e98688
Published 2014-1-1
DOI 10.1371/journal.pone.0098688
PII PONE-D-13-43923
PMID 24896609
PMC PMC4045826
MeSH Animals Biosynthetic Pathways Cloning, Molecular Eels / classification Eels / physiology* Gene Expression Glucuronosyltransferase / chemistry Glucuronosyltransferase / genetics* Glucuronosyltransferase / metabolism Hyaluronic Acid / biosynthesis* Male Phylogeny RNA, Messenger / genetics Sequence Analysis, DNA
IF 2.74
Human and Animal Cells Hepa-E1(RCB1155)