Reference - Detail
| RRC ID | 68938 |
|---|---|
| Author | Shimizu K, Iyoda T, Sanpei A, Nakazato H, Okada M, Ueda S, Kato-Murayama M, Murayama K, Shirouzu M, Harada N, Hidaka M, Fujii SI. |
| Title | Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2. |
| Journal | Commun Biol |
| Abstract |
SARS-CoV-2-specific CD8+ T cells are scarce but detectable in unexposed healthy donors (UHDs). It remains unclear whether pre-existing human coronavirus (HCoV)-specific CD8+ T cells are converted to functionally competent T cells cross-reactive to SARS-CoV-2. Here, we identified the HLA-A24-high binding, immunodominant epitopes in SARS-CoV-2 spike region that can be recognized by seasonal coronavirus-specific CD8+ T cells from HLA-A24+ UHDs. Cross-reactive CD8+ T cells were clearly reduced in patients with hematological malignancy, who are usually immunosuppressed, compared to those in UHDs. Furthermore, we showed that CD8+ T cells in response to a selected dominant epitope display multifunctionality and cross-functionality across HCoVs in HLA-A24+ donors. Cross-reactivity of T-cell receptors isolated from them exhibited selective diversity at the single-cell level. Taken together, when stimulated well by immunodominant epitopes, selective pre-existing CD8+ T cells with high functional avidity may be cross-reactive against SARS-CoV-2. |
| Volume | 4(1) |
| Pages | 1365 |
| Published | 2021-12-2 |
| DOI | 10.1038/s42003-021-02885-6 |
| PII | 10.1038/s42003-021-02885-6 |
| PMID | 34857854 |
| PMC | PMC8640030 |
| MeSH | Antigens, Viral / immunology* CD8-Positive T-Lymphocytes / immunology COVID-19 / immunology Cross Reactions Humans Immunodominant Epitopes / immunology* Receptors, Antigen, T-Cell / immunology* SARS-CoV-2 / immunology* T-Lymphocytes, Cytotoxic / immunology* |
| IF | 4.165 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1349 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | SKW-3(RCB1168) |