RRC ID 69044
Author Akhmetova K, Balasov M, Chesnokov I.
Title Drosophila STING protein has a role in lipid metabolism.
Journal Elife
Abstract Stimulator of interferon genes (STING) plays an important role in innate immunity by controlling type I interferon response against invaded pathogens. In this work, we describe a previously unknown role of STING in lipid metabolism in Drosophila. Flies with STING deletion are sensitive to starvation and oxidative stress, have reduced lipid storage, and downregulated expression of lipid metabolism genes. We found that Drosophila STING interacts with lipid synthesizing enzymes acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN). ACC and FASN also interact with each other, indicating that all three proteins may be components of a large multi-enzyme complex. The deletion of Drosophila STING leads to disturbed ACC localization and decreased FASN enzyme activity. Together, our results demonstrate a previously undescribed role of STING in lipid metabolism in Drosophila.
Volume 10
Published 2021-9-1
DOI 10.7554/eLife.67358
PII 67358
PMID 34467853
PMC PMC8443252
MeSH Acetyl-CoA Carboxylase / genetics Acetyl-CoA Carboxylase / metabolism Animals Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila Proteins* / physiology Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Drosophila melanogaster / physiology Fatty Acid Synthases / genetics Fatty Acid Synthases / metabolism Female Gene Deletion Gene Knockout Techniques Lipid Metabolism / genetics* Male Membrane Proteins* / genetics Membrane Proteins* / metabolism Membrane Proteins* / physiology
IF 7.08
Resource
Drosophila HMJ23183