RRC ID 69147
Author Wei XP, Collie M, Dempsey B, Fortin G, Yackle K.
Title A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.
Journal Neuron
Abstract Human speech can be divided into short, rhythmically timed elements, similar to syllables within words. Even our cries and laughs, as well as the vocalizations of other species, are periodic. However, the cellular and molecular mechanisms underlying the tempo of mammalian vocalizations remain unknown. Furthermore, even the core cells that produce vocalizations remain ill-defined. Here, we describe rhythmically timed neonatal mouse vocalizations that occur within single breaths and identify a brainstem node that is necessary for and sufficient to structure these cries, which we name the intermediate reticular oscillator (iRO). We show that the iRO acts autonomously and sends direct inputs to key muscles and the respiratory rhythm generator in order to coordinate neonatal vocalizations with breathing, as well as paces and patterns these cries. These results reveal that a novel mammalian brainstem oscillator embedded within the conserved breathing circuitry plays a central role in the production of neonatal vocalizations.
Volume 110(4)
Pages 644-657.e6
Published 2022-2-16
DOI 10.1016/j.neuron.2021.12.014
PII S0896-6273(21)01031-X
PMID 34998469
PMC PMC8857054
MeSH Animals Animals, Newborn Brain Stem* / physiology Crying* Humans Mammals Mice Respiration Speech
IF 14.415
Mice RBRC10109