| RRC ID |
69199
|
| Author |
Doi M, Morita N, Okuzawa T, Ohgiya S, Okamoto D, Sato K, Ito Y, Matsuura H, Hashidoko Y.
|
| Title |
Pinellic Acid Isolated from Quercetin-rich Onions has a Peroxisome Proliferator-Activated Receptor-Alpha/Gamma (PPAR-α/γ) Transactivation Activity.
|
| Journal |
Planta Med
|
| Abstract |
Quercetin, a flavonol, is a functional compound that is abundant in onions and is known to have antioxidant and anti-inflammatory effects. Quercetin and its glucoside are known to function as peroxisome proliferator-activated receptor (PPAR) ligands and showed high PPAR-α transactivation activity but little PPAR-γ transactivation activity in some reports. In this study, we demonstrated that an aqueous extract of a quercetin-rich onion cultivar increased transactivation activities not only of PPAR-α but also of PPAR-γ. We isolated (9S,12S,13S)-(10E)-9,12,13-trihydroxyoctadec-10-enoic acid (pinellic acid) obtained from the aqueous extract using PPAR-γ transactivation as an index. Furthermore, it was revealed that pinellic acid could transactivate PPAR-α. Our findings are the first report mentioned showing that trihydroxyoctadec-10-enoic acids showed PPAR-α/γ transactivation activities.
|
| Volume |
88(6)
|
| Pages |
440-446
|
| Published |
2022-5-1
|
| DOI |
10.1055/a-1345-9471
|
| PMID |
35038752
|
| MeSH |
Fatty Acids, Unsaturated
Onions / metabolism
PPAR alpha / metabolism
PPAR gamma* / metabolism
Quercetin* / pharmacology
Transcriptional Activation
|
| IF |
2.687
|
| Resource |
| Human and Animal Cells |
CV-1(RCB0160) |
