Reference - Detail
| RRC ID | 69212 |
|---|---|
| Author | Zhang J, Nishimoto Y, Tokuda H, Suzuki N, Yasukawa K, Kitdamrongtham W, Akazawa H, Manosroi A, Manosroi J, Akihisa T. |
| Title | Cancer chemopreventive effect of bergenin from Peltophorum pterocarpum wood. |
| Journal | Chem Biodivers |
| Abstract |
The aqueous extract of Peltophorum pterocarpum (Fabaceae) wood exhibited potent inhibitory effects against EpsteinBarr virus early antigen (EBV-EA) activation induced with 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and against melanogenesis in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 melanoma cells, as well as potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging activity. Two phenolic acid derivatives, bergenin (1) and gallic acid (2), were isolated from the ethyl acetate (AcOEt)-soluble fraction obtained from the extract. Compound 1 exhibited potent inhibitory effect against EBV-EA activation and against skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter. Both compounds 1 and 2 exhibited melanogenesis-inhibitory activities in α-MSH-stimulated B16 melanoma cells, and, in addition, compound 2 showed strong DPPH radical-scavenging activity. |
| Volume | 10(10) |
| Pages | 1866-75 |
| Published | 2013-10-1 |
| DOI | 10.1002/cbdv.201300182 |
| PMID | 24130029 |
| MeSH | Animals Anticarcinogenic Agents / chemistry* Anticarcinogenic Agents / pharmacology Anticarcinogenic Agents / therapeutic use Anticarcinogenic Agents / toxicity Antigens, Viral / chemistry Antigens, Viral / metabolism Apoptosis / drug effects Benzopyrans / chemistry* Benzopyrans / pharmacology Benzopyrans / therapeutic use Cell Line, Tumor Fabaceae / chemistry* Fabaceae / metabolism Free Radical Scavengers / chemistry* Free Radical Scavengers / isolation & purification Gallic Acid / chemistry* Gallic Acid / pharmacology Gallic Acid / therapeutic use HL-60 Cells Humans Melanins / antagonists & inhibitors Melanins / metabolism Mice Plant Extracts / chemistry Plant Extracts / pharmacology Plant Extracts / therapeutic use Skin Neoplasms / drug therapy Skin Neoplasms / prevention & control |
| IF | 2.039 |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) HL60(RCB0041) |