Reference - Detail
| RRC ID | 69216 |
|---|---|
| Author | Tomono S, Yasue Y, Miyoshi N, Ohshima H. |
| Title | Cytotoxic effects of secosterols and their derivatives on several cultured cells. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
The cytotoxic effects of various oxysterols on several culture cells were examined. Ozonolysis products of cholesterol, secosterols (3β-hydroxy-5-oxo-5,6-secocholestan-6-al) and its aldolization product (3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde) and their keto alcohol and acid derivatives, were found to have potent cytotoxic activities, as compared with major endogenous oxysterols such as 5β,6β-epoxycholesterol, 7β-hydroxycholesterol, 7-ketocholesterol, and 25-hydroxycholesterol. Secosterols might play important roles in tissue damage and inflammation-associated diseases. |
| Volume | 77(3) |
| Pages | 651-3 |
| Published | 2013-1-1 |
| DOI | 10.1271/bbb.120758 |
| PII | DN/JST.JSTAGE/bbb/120758 |
| PMID | 23470737 |
| MeSH | Animals Cell Line Cell Survival / drug effects Cholestanones / chemistry* Cholestanones / toxicity* Cytotoxins / chemistry* Cytotoxins / toxicity* Humans Secosteroids / chemistry* Secosteroids / toxicity* |
| IF | 1.516 |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |