RRC ID 69259
著者 Do KM, Kodama T, Shin MK, Nu LHT, Nguyen HM, Dang SV, Shiokawa KI, Hayakawa Y, Morita H.
タイトル Marginols A‒H, unprecedented pimarane diterpenoids from Kaempferia marginata and their NO inhibitory activities.
ジャーナル Phytochemistry
Abstract Kaempferia marginata rhizomes are used as an herb in food and as traditional medicine for the treatment of inflammatory-related diseases in Asian countries. In contrast to the previously reported phytochemical investigation of Thai and Chinese K. marginata rhizomes, which demonstrated the presence of sandaracopimaradiene and ent-sandaracopimaradiene, our first investigation of Vietnamese K. marginata rhizomes led to the isolation of eight undescribed pimarane diterpenoids, marginols A‒H, along with 18 known pimarane diterpenoids. The structures of these compounds were elucidated by spectroscopic techniques, including 1D and 2D NMR, HRESIMS, and CD spectroscopy and/or by comparisons of their NMR data with previously reported data. Furthermore, evaluations of the NO production inhibitory activity against LPS-stimulated RAW264.7 cells revealed that the undescribed compounds, marginols B and D‒G, and the known compounds, sandaracopimaradien-6β,9α-diol-1-one and 6-acetoxysandaracopimardien-9-ol-1-one, showed potent activities. These results provide insights into the chemodiversity of Vietnamese K. marginata rhizomes as well as their traditional usage from the viewpoint of their chemical constituents.
巻・号 196
ページ 113109
公開日 2022-4-1
DOI 10.1016/j.phytochem.2022.113109
PII S0031-9422(22)00025-5
PMID 35091214
MeSH Abietanes / chemistry Abietanes / pharmacology Diterpenes* / chemistry Molecular Structure Rhizome / chemistry Thailand Zingiberaceae* / chemistry
IF 3.044
リソース情報
ヒト・動物細胞 RAW 264(RCB0535)