論文 - 詳細
| RRC ID | 69340 |
|---|---|
| 著者 | Nguyen MT, Nguyen NT, Nguyen KD, Dau HT, Nguyen HX, Dang PH, Le TM, Nguyen Phan TH, Tran AH, Nguyen BD, Ueda JY, Awale S. |
| タイトル | Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity. |
| ジャーナル | Planta Med |
| Abstract |
Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions is a novel antiausterity strategy in anticancer drug discovery. In this study, the methanolic extract of the leaves of Artocarpus altilis showed 100 % preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions at a concentration of 50 µg/mL. Further investigation of this extract led to the isolation of eight new geranylated dihydrochalcones named sakenins A-H (1-8) together with four known compounds (9-12). Among them, sakenins F (6) and H (8) were identified as potent preferentially cytotoxic candidates with PC50 values of 8.0 µM and 11.1 µM, respectively. |
| 巻・号 | 80(2-3) |
| ページ | 193-200 |
| 公開日 | 2014-2-1 |
| DOI | 10.1055/s-0033-1360181 |
| PMID | 24431013 |
| MeSH | Artocarpus / chemistry* Cell Line, Tumor Chalcones / pharmacology* Cytotoxins / chemistry Cytotoxins / isolation & purification Cytotoxins / pharmacology* Humans Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms / pathology Phytotherapy Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology* Tumor Microenvironment |
| IF | 2.687 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |