RRC ID 69453
Author Matsuura N, Gamo K, Miyachi H, Iinuma M, Kawada T, Takahashi N, Akao Y, Tosa H.
Title γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ.
Journal Biosci Biotechnol Biochem
Abstract We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated γ-mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that γ-mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.
Volume 77(12)
Pages 2430-5
Published 2013-1-1
DOI 10.1271/bbb.130541
PII DN/JST.JSTAGE/bbb/130541
PMID 24317060
MeSH Animals Cell Line Fruit / chemistry* Garcinia mangostana / chemistry* Gene Expression Regulation / drug effects Hepatocytes / drug effects Hepatocytes / metabolism Humans Ion Channels / genetics Mitochondrial Proteins / genetics PPAR alpha / agonists* PPAR alpha / metabolism* PPAR delta / agonists* PPAR delta / metabolism* Rats Uncoupling Protein 3 Xanthones / isolation & purification Xanthones / pharmacology*
IF 1.516
Human and Animal Cells COS-1(RCB0143)