論文 - 詳細
RRC ID | 69453 |
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著者 | Matsuura N, Gamo K, Miyachi H, Iinuma M, Kawada T, Takahashi N, Akao Y, Tosa H. |
タイトル | γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ. |
ジャーナル | Biosci Biotechnol Biochem |
Abstract |
We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated γ-mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that γ-mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome. |
巻・号 | 77(12) |
ページ | 2430-5 |
公開日 | 2013-1-1 |
DOI | 10.1271/bbb.130541 |
PII | DN/JST.JSTAGE/bbb/130541 |
PMID | 24317060 |
MeSH | Animals Cell Line Fruit / chemistry* Garcinia mangostana / chemistry* Gene Expression Regulation / drug effects Hepatocytes / drug effects Hepatocytes / metabolism Humans Ion Channels / genetics Mitochondrial Proteins / genetics PPAR alpha / agonists* PPAR alpha / metabolism* PPAR delta / agonists* PPAR delta / metabolism* Rats Uncoupling Protein 3 Xanthones / isolation & purification Xanthones / pharmacology* |
IF | 1.516 |
リソース情報 | |
ヒト・動物細胞 | COS-1(RCB0143) |