Reference - Detail
| RRC ID | 69596 |
|---|---|
| Author | Hoshi H, Saito H, Iijima H, Uchida M, Wada T, Ito G, Tanaka H, Sawada T, Hirakawa K. |
| Title | Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound. |
| Journal | Oncol Rep |
| Abstract |
Protein-bound polysaccharide K (PSK) is extracted and purified from Coriolus versicolor (CM101), and is used as an anti-cancer agent. In this study, focusing on the direct actions of PSK, we investigated whether PSK reaches tumor and immune tissues with its active structure remaining intact, and the direct action of PSK was evaluated by its antitumor effects against MethA fibrosarcomas implanted in immunodeficient NOD/SCID mice. The results obtained suggest that PSK reaches the tumor tissue in its active form and exhibits antitumor effects against MethA cells. |
| Volume | 25(4) |
| Pages | 905-13 |
| Published | 2011-4-1 |
| DOI | 10.3892/or.2011.1155 |
| PMID | 21249323 |
| MeSH | Animals Antibodies, Anti-Idiotypic / therapeutic use* Antibodies, Monoclonal / therapeutic use* Antineoplastic Agents / therapeutic use* Blotting, Western Enzyme-Linked Immunosorbent Assay Female Fibrosarcoma / immunology Fibrosarcoma / therapy* Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID Proteoglycans / immunology Proteoglycans / therapeutic use* Tumor Cells, Cultured |
| IF | 3.417 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | J774.1(RCB0434) |