| RRC ID |
69596
|
| Author |
Hoshi H, Saito H, Iijima H, Uchida M, Wada T, Ito G, Tanaka H, Sawada T, Hirakawa K.
|
| Title |
Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound.
|
| Journal |
Oncol Rep
|
| Abstract |
Protein-bound polysaccharide K (PSK) is extracted and purified from Coriolus versicolor (CM101), and is used as an anti-cancer agent. In this study, focusing on the direct actions of PSK, we investigated whether PSK reaches tumor and immune tissues with its active structure remaining intact, and the direct action of PSK was evaluated by its antitumor effects against MethA fibrosarcomas implanted in immunodeficient NOD/SCID mice. The results obtained suggest that PSK reaches the tumor tissue in its active form and exhibits antitumor effects against MethA cells.
|
| Volume |
25(4)
|
| Pages |
905-13
|
| Published |
2011-4-1
|
| DOI |
10.3892/or.2011.1155
|
| PMID |
21249323
|
| MeSH |
Animals
Antibodies, Anti-Idiotypic / therapeutic use*
Antibodies, Monoclonal / therapeutic use*
Antineoplastic Agents / therapeutic use*
Blotting, Western
Enzyme-Linked Immunosorbent Assay
Female
Fibrosarcoma / immunology
Fibrosarcoma / therapy*
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
Mice, SCID
Proteoglycans / immunology
Proteoglycans / therapeutic use*
Tumor Cells, Cultured
|
| IF |
3.417
|
| Resource |
| Human and Animal Cells |
J774.1(RCB0434) |
