| RRC ID |
69613
|
| 著者 |
Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, Sugawara M, Iseki K.
|
| タイトル |
In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid.
|
| ジャーナル |
Int J Pharm
|
| Abstract |
Dietary polyphenols are thought to be beneficial for human health as antioxidants. Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of caffeic acid and quinic acid. Although these polyphenols have received much attention, there is little evidence indicating a relationship between the effect and the rate of absorption. In this study, we focused on the beneficial effects of chlorogenic acid and caffeic acid, a major metabolite of chlorogenic acid. We carried out in vitro and in vivo experiments. In the in vitro study, caffeic acid had stronger antioxidant activity than that of chlorogenic acid. The uptake of chlorogenic acid by Caco-2 cells was much less than that of caffeic acid. The physiological importance of an orally administered compound depends on its availability for intestinal absorption and subsequent interaction with target tissues. We then used an intestinal ischemia-reperfusion model to evaluate antioxidant activities in vivo. We found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury. Since caffeic acid has a stronger antioxidant activity than that of chlorogenic acid and chlorogenic acid is hydrolyzed into caffeic acid in the intestine, it is possible that caffeic acid plays a major role in the protective effect of chlorogenic acid against ischemia-reperfusion injury.
|
| 巻・号 |
403(1-2)
|
| ページ |
136-8
|
| 公開日 |
2011-1-17
|
| DOI |
10.1016/j.ijpharm.2010.09.035
|
| PII |
S0378-5173(10)00755-6
|
| PMID |
20933071
|
| MeSH |
Animals
Antioxidants / chemistry
Antioxidants / pharmacokinetics
Antioxidants / pharmacology*
Antioxidants / therapeutic use
Caco-2 Cells
Caffeic Acids / chemistry
Caffeic Acids / pharmacokinetics
Caffeic Acids / pharmacology*
Caffeic Acids / therapeutic use
Capillary Permeability
Chlorogenic Acid / chemistry
Chlorogenic Acid / pharmacokinetics
Chlorogenic Acid / pharmacology*
Chlorogenic Acid / therapeutic use
Humans
Intestinal Absorption
Intestine, Small / blood supply
Intestine, Small / drug effects
Intestine, Small / metabolism*
Male
Oxidation-Reduction
Rats
Rats, Wistar
Reperfusion Injury / metabolism
Reperfusion Injury / prevention & control*
Superoxides / analysis
|
| IF |
4.845
|
| リソース情報 |
| ヒト・動物細胞 |
CACO-2(RCB0988) |
