論文 - 詳細
| RRC ID | 69616 |
|---|---|
| 著者 | Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano T, Takahashi M, Nishizawa H, Handayaningshi AE, Fukuoka H, Tobita M, Saitoh T, Tojo K, Mokubo A, Morinobu A, Iida K, Kaji H, Seino S, Chihara K, Takahashi Y. |
| タイトル | Adult combined GH, prolactin, and TSH deficiency associated with circulating PIT-1 antibody in humans. |
| ジャーナル | J Clin Invest |
| Abstract |
The pituitary-specific transcriptional factor-1 (PIT-1, also known as POU1F1), is an essential factor for multiple hormone-secreting cell types. A genetic defect in the PIT-1 gene results in congenital growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiency. Here, we investigated 3 cases of adult-onset combined GH, PRL, and TSH deficiencies and found that the endocrinological phenotype in each was linked to autoimmunity directed against the PIT-1 protein. We detected anti-PIT-1 antibody along with various autoantibodies in the patients' sera. An ELISA-based screening revealed that this antibody was highly specific to the disease and absent in control subjects. Immunohistochemical analysis revealed that PIT-1-, GH-, PRL-, and TSH-positive cells were absent in the pituitary of patient 2, who also had a range of autoimmune endocrinopathies. These clinical manifestations were compatible with the definition of autoimmune polyendocrine syndrome (APS). However, the main manifestations of APS-I--hypoparathyroidism and Candida infection--were not observed and the pituitary abnormalities were obviously different from the hypophysitis associated with APS. These data suggest that these patients define a unique "anti-PIT-1 antibody syndrome," related to APS. |
| 巻・号 | 121(1) |
| ページ | 113-9 |
| 公開日 | 2011-1-1 |
| DOI | 10.1172/JCI44073 |
| PII | 44073 |
| PMID | 21123951 |
| PMC | PMC3007153 |
| MeSH | Adult Aged Antibody Specificity Autoantibodies / blood* Human Growth Hormone / deficiency* Humans Immunohistochemistry Male Pituitary Gland / metabolism Polyendocrinopathies, Autoimmune / blood Polyendocrinopathies, Autoimmune / immunology* Polyendocrinopathies, Autoimmune / metabolism Prolactin / deficiency* Thyrotropin / deficiency* Transcription Factor Pit-1 / antagonists & inhibitors* Transcription Factor Pit-1 / deficiency Transcription Factor Pit-1 / immunology* |
| IF | 11.864 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | COS-7(RCB0539) 293T(RCB2202) |