RRC ID 69683
Author Choi NH, Kim JG, Yang DJ, Kim YS, Yoo MA.
Title Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor.
Journal Aging Cell
Abstract Age-associated changes in stem cell populations have been implicated in age-related diseases, including cancer. However, little is known about the underlying molecular mechanisms that link aging to the modulation of adult stem cell populations. Drosophila midgut is an excellent model system for the study of stem cell renewal and aging. Here we describe an age-related increase in the number and activity of intestinal stem cells (ISCs) and progenitor cells in Drosophila midgut. We determined that oxidative stress, induced by paraquat treatment or loss of catalase function, mimicked the changes associated with aging in the midgut. Furthermore, we discovered an age-related increase in the expression of PVF2, a Drosophila homologue of human PDGF/VEGF, which was associated with and required for the age-related changes in midgut ISCs and progenitor cell populations. Taken together, our findings suggest that PDGF/VEGF may play a central role in age-related changes in ISCs and progenitor cell populations, which may contribute to aging and the development of cancer stem cells.
Volume 7(3)
Pages 318-34
Published 2008-6-1
DOI 10.1111/j.1474-9726.2008.00380.x
PMID 18284659
PMC PMC2408640
MeSH Animals Catalase / physiology Cell Differentiation / physiology Cellular Senescence / physiology* Drosophila melanogaster / cytology Drosophila melanogaster / physiology* Immunochemistry Intestines / cytology Intestines / physiology Oxidative Stress / physiology RNA / genetics Reverse Transcriptase Polymerase Chain Reaction Stem Cells / cytology Stem Cells / physiology Vascular Endothelial Growth Factors / genetics Vascular Endothelial Growth Factors / physiology*
IF 7.238
Drosophila DGRC#104863